STX107 is a negative allosteric modulator (NAM) of the metabotropic glutamate 5 (mGlu5) receptor, exhibiting a pKi of 8.32. This compound effectively inhibits glutamate-induced calcium mobilization, inositol monophosphate (IP1) accumulation, and ERK1/2 phosphorylation. Additionally, STX107 prevents glutamate-induced mGlu5 internalization, making it a valuable tool for researching mGlu5 receptor signaling pathways and potential therapeutic applications for neurological disorders.
STX107 is a negative allosteric modulator (NAM) of the metabotropic glutamate 5 (mGlu5) receptor, exhibiting a pKi of 8.32. This compound effectively inhibits glutamate-induced calcium mobilization, inositol monophosphate (IP1) accumulation, and ERK1/2 phosphorylation. Additionally, STX107 prevents glutamate-induced mGlu5 internalization, making it a valuable tool for researching mGlu5 receptor signaling pathways and potential therapeutic applications for neurological disorders.
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