Fig. 1 · Structure
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SU11652
RTK Inhibitor
SU11652 is a potent inhibitor of receptor tyrosine kinases (RTKs) with specific activity against several members of the split kinase family, including VEGFR, FGFR, PDGFR, and Kit. This compound is particularly relevant for research applications involving spontaneous cancers characterized by Kit mutations. By targeting these critical pathways, SU11652 facilitates the investigation of tumorigenesis and potential therapeutic strategies in malignancies driven by aberrant RTK signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 326914-10-7 |
| Applications | RTK Inhibitor |
| Formula | C22H27ClN4O2 |
| Molecular Weight | 414.93 |
| SMILES | O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(Cl)C=C3)=O)=C1C)NCCN(CC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.