SU9516

Catalog No.: A14318

CDK2 inhibitor

SU9516 Chemical Structure

CAS NO. 377090-84-1

SU9516 is a potent, selective cdk2 inhibitor. It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$200.00
50 mg
$320.00
10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SU9516 is a potent, selective cdk2 inhibitor. It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.
Targets
Target Value
CDK2IC50: 22nM
CDK1IC50: 40nM
CDK4IC50: 200nM
PKCIC50: >10μM
p38IC50: >10μM
PDGFRIC50: 18μM
EGFRIC50: >100μM
In vitro DMSO 48 mg/mL (198.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol 12 mg/mL heating (49.74 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.45 mL 207.25 mL 414.51 mL
0.5 mM 8.29 mL 41.45 mL 82.9 mL
1 mM 4.15 mL 20.73 mL 41.45 mL
5 mM 0.83 mL 4.15 mL 8.29 mL

*The above data is based on the productmolecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14318
Actions Inhibitor
M. Wt 241.25
Formula C13H11N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 377090-84-1
Synonyms SU 9516, SU-9516
SMILES COC1=CC\2=C(C=C1)NC(=O)/C2=C\C3=CN=CN3

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