Target & Activity
| Target | Activity | Value |
|---|---|---|
| CDK2 | IC50 | 22nM |
| CDK1 | IC50 | 40nM |
| CDK4 | IC50 | 200nM |
| PKC | IC50 | >10μM |
| p38 | IC50 | >10μM |
| PDGFR | IC50 | 18μM |
| EGFR | IC50 | >100μM |
7 targets · Scroll to view more
Fig. 1 · Structure
Documents & Downloads
SU9516
Cat. No.
A14318
CAS
377090-84-1
CDK2 inhibitor
SU9516 is a potent, selective cdk2 inhibitor. It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 377090-84-1 |
| Applications | CDK2 inhibitor |
| Formula | C13H11N3O2 |
| Molecular Weight | 241.25 |
| SMILES | COC1=CC\2=C(C=C1)NC(=O)/C2=C\C3=CN=CN3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 44 mg/mL (182.38 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 11 mg/mL (45.6 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.