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Sudemycin D6

Pre-mRNA Splicing Modulator

Sudemycin D6 is a selective pre-mRNA splicing modulator that exhibits significant antitumor properties. It alters splice site usage specifically in DUSP11 and SRRM1 pre-mRNA, leading to reduced survival and altered cell cycle dynamics in hematopoietic cells with mutant U2AF1. Additionally, Sudemycin D6 effectively mitigates the hematopoietic progenitor cell expansion associated with U2AF1(S34F) transgenic mice. This compound is valuable for cancer research focused on splicing mechanisms and hematologic malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1510837-67-8
Applications	Pre-mRNA Splicing Modulator
Formula	C₂₇H₄₂N₂O₅
Molecular Weight	474.63
SMILES	CNC(O[C@@H](C)/C=C\C(N[C@@H](CC1)CC[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.