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Sudemycin K

SF3B1 Inhibitor

Sudemycin K is a selective inhibitor targeting the splicing factor SF3B1. It disrupts the recognition of branch point sequences in pre-mRNA by U2 snRNP, leading to tumor-specific splicing deregulation and subsequent apoptosis. Sudemycin K is particularly relevant for research on SF3B1-mutated malignancies, including chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS).

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2071636-70-7
Applications	SF3B1 Inhibitor
Formula	C₂₉H₄₆N₂O₄
Molecular Weight	486.69
SMILES	C[C@H](NC(C(C)C)=O)/C=C\C(NC1CCC(C/C=C(C)/C=C/[C@@H](OC(C)(C)C2)C[C@@]32CO3)CC1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.