Fig. 1 · Structure
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Sunitinib glucuronate
Multi-targeted RTK Inhibitor
Sunitinib glucuronate is a multi-targeted receptor tyrosine kinase inhibitor that demonstrates potent inhibition of VEGFR2 and PDGFRβ, with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, it effectively disrupts the autophosphorylation of Ire1α, thereby inhibiting its RNase activation. This compound is valuable for research applications involving cancer biology, angiogenesis, and cell signaling pathways that are regulated by receptor tyrosine kinases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1818285-48-1 |
| Applications | Multi-targeted RTK Inhibitor |
| Formula | C28H37FN4O9 |
| Molecular Weight | 592.61 |
| Synonyms | SU 11248 glucuronate |
| SMILES | O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O.O=C(/C(C1=C2)=C\C3=C(C(C(NCCN(CC)CC)=O)=C(N3)C)C)NC1=CC=C2F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.