Fig. 1 · Structure
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Supinoxin
Anti-Cancer Agent
Supinoxin is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and serves as a first-in-class anti-cancer agent. By targeting Y593 phosphorylated-p68, Supinoxin disrupts the nuclear translocation of β-catenin, leading to induction of apoptosis in cancer cells. This compound has demonstrated significant growth inhibition in triple-negative breast cancer (TNBC) cell lines, with IC50 values between 10 nM and 20 nM, making it a valuable tool for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 888478-45-3 |
| Applications | Anti-Cancer Agent |
| Formula | C22H24FN5O4 |
| Molecular Weight | 441.46 |
| Synonyms | RX-5902 |
| SMILES | O=C(N1CCN(C2=CC(OC)=CC(OC)=C2)CC1)NC3=NC4=CC(F)=CC=C4N=C3OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.