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Sutetinib maleate

Tyrosine Kinase Inhibitor

Sutetinib maleate is a potent orally active tyrosine kinase inhibitor, targeting key pathways involved in tumor growth and angiogenesis, including VEGFR and PDGFR, with Ki values of 0.009 µM and 0.008 µM respectively. This compound effectively inhibits the proliferation and migration of endothelial cells and fibroblasts while disrupting tubular structure formation. Additionally, Sutetinib maleate demonstrates broad-spectrum antitumor efficacy in both in vitro and in vivo models, making it a valuable tool in cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1701408-75-4
Applications	Tyrosine Kinase Inhibitor
Formula	C₃₀H₂₉N₅O₆
Molecular Weight	555.58
SMILES	OC(/C=C\C(O)=O)=O.CCOC(C(NC(/C=C/CN(C)C)=O)=C1)=CC2=C1C(NC3=CC(C#C)=CC=C3)=C(C#N)C=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.