Fig. 1 · Structure
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SW157765
GLUT8 Inhibitor
SW157765 is a selective inhibitor of the non-canonical glucose transporter GLUT8 (SLC2A8). It demonstrates significant biological activity by selectively targeting KRAS/KEAP1 double mutant non-small cell lung cancer (NSCLC) cells, which exhibit heightened sensitivity due to the interplay between KRAS and NRF2 that modulates metabolic and xenobiotic gene regulatory programs. This reagent is valuable for research related to cancer metabolism and therapeutic strategies in NSCLC.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 332063-87-3 |
| Applications | GLUT8 Inhibitor |
| Formula | C19H13N3O3 |
| Molecular Weight | 331.32 |
| SMILES | O=C(NC1=CC=C(OC(C2=CC=NC=C2)=N3)C3=C1)/C=C/C4=CC=CO4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.