Fig. 1 · Structure
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SYHA1815
RET Inhibitor
SYHA1815 is a potent, orally bioavailable RET inhibitor, exhibiting an IC50 of 0.9 nmol/L. This compound demonstrates high selectivity for RET over KDR, with an IC50 of 15.9 nmol/L. SYHA1815 effectively arrests the G1 phase of the cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc, making it a valuable tool in cancer research and potential therapeutic applications targeting RET-related malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2760195-67-1 |
| Applications | RET Inhibitor |
| Formula | C27H26ClF4N5O |
| Molecular Weight | 547.97 |
| SMILES | CN(CC1)CCN1CC2=C(C(F)(F)F)C=C(NC(C3=CC(F)=CC(C#CC4=CC=CN=C4N)=C3)=O)C=C2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.