Syn-516 is an inhibitor targeting α-synuclein (α-Syn) by specifically engaging the 5' untranslated region (5'UTR) of α-Syn mRNA, resulting in an IC50 of 1.8 μM. This compound effectively inhibits the translation of α-Syn protein, demonstrating potential to alleviate motor dysfunction and colonic motility issues linked to α-Syn overexpression in murine models. Syn-516 serves as a valuable tool for research into neurodegenerative diseases, including Parkinson's disease and Lewy body dementia.
Syn-516 is an inhibitor targeting α-synuclein (α-Syn) by specifically engaging the 5' untranslated region (5'UTR) of α-Syn mRNA, resulting in an IC50 of 1.8 μM. This compound effectively inhibits the translation of α-Syn protein, demonstrating potential to alleviate motor dysfunction and colonic motility issues linked to α-Syn overexpression in murine models. Syn-516 serves as a valuable tool for research into neurodegenerative diseases, including Parkinson's disease and Lewy body dementia.
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