Fig. 1 · Structure
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T-1101
Hec1 Inhibitor
T-1101 is a potent inhibitor of the mitotic regulator Hec1, which is highly expressed in various cancers. It effectively disrupts the interaction between Hec1 and NEK2, demonstrating cytotoxic effects in human liver cancer cells with a GI50 range of 15-70 nM. Furthermore, T-1101 induces apoptosis in Huh-7 cells and shows significant antitumor activity in mouse models, making it a valuable compound for cancer research and therapeutic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1438638-83-5 |
| Applications | Hec1 Inhibitor |
| Formula | C24H23N5O3S2 |
| Molecular Weight | 493.60 |
| Synonyms | TAI-95 |
| SMILES | O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.