Fig. 1 · Structure
Documents & Downloads
T-3861174
Aminoacyl-tRNA Synthetase Inhibitor
T-3861174 is an inhibitor of prolyl-tRNA synthetase, selectively targeting aminoacyl-tRNA synthetase to modulate translation without complete inhibition. This compound activates the GCN2-ATF4 pathway, leading to apoptosis in various tumor cell lines such as SK-MEL-2. T-3861174 exhibits significant antitumor efficacy in multiple xenograft models, while maintaining body weight, making it a valuable tool for cancer research and therapeutic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2209057-94-1 |
| Applications | Aminoacyl-tRNA Synthetase Inhibitor |
| Formula | C26H25FN6O2 |
| Molecular Weight | 472.51 |
| SMILES | O=C(C1=NC(C)=CC(N2C([C@@](C3CC3)(C#N)CC2)=O)=C1)NCC4=CC(C5=CN(C)N=C5)=CC(F)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.