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Catalog No.: A12652

LXR/FXR agonist


T0901317 Chemical Structure

CAS NO. 293754-55-9

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively

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10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tian Yongsong, .et al. Tritium hydrogen-isotope exchange with electron-poor tertiary benzenesulfonamide moiety; application in late-stage labeling of T0901317, J Labelled Comp Radiopharm, 2022, Feb;65(2):36-44 PMID: 34957593

Biological Activity

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively
50 nM(EC50)5 μM(EC50)
In vitro (25°C) DMSO 88 mg/mL (182.82 mM)
Water Insoluble
Ethanol 88 mg/mL (182.82 mM)
In vivo 2% DMSO+35% PEG 300+5% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.78 mL 103.88 mL 207.76 mL
0.5 mM 4.16 mL 20.78 mL 41.55 mL
1 mM 2.08 mL 10.39 mL 20.78 mL
5 mM 0.42 mL 2.08 mL 4.16 mL

*The above data is based on the productmolecular weight 481.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12652
Actions Agonist
CAS No. 293754-55-9
Formula C17H12F9NO3S
M. Wt 481.33
Purity >98%
SMILES C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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