Fig. 1 · Structure
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T2AA
PCNA Inhibitor
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that disrupts DNA repair mechanisms, leading to an increased formation of double-strand breaks (DSBs). This compound promotes necroptosis and induces cell cycle arrest in the G1 phase, making it a valuable tool for research focused on cell death and DNA damage response pathways. T2AA can be utilized in studies investigating the effects of inhibited PCNA activity on genomic stability and cellular proliferation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1380782-27-3 |
| Applications | PCNA Inhibitor |
| Formula | C15H15I2NO3 |
| Molecular Weight | 511.09 |
| SMILES | IC(C=C(C[C@H](N)CO)C=C1I)=C1OC2=CC=C(O)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.