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Tabernanthine

Sinoatrial Node Receptor Inhibitor

Tabernanthine is a selective inhibitor of sinoatrial node receptors, functioning primarily as a negative chronotropic and negative inotropic agent. By directly modulating heart rhythm and myocardial contractility, it effectively slows heart rate and reduces myocardial contractility without involvement of vagal nerve or cholinergic pathways, demonstrating atropine resistance and non-cholinergic binding properties. This compound is valuable for cardiovascular pharmacology research, particularly in investigations of sinoatrial node functionality, mechanisms underlying bradycardia, and the analysis of cardiac receptor subtype variations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	83-94-3
Applications	Sinoatrial Node Receptor Inhibitor
Formula	C₂₀H₂₆N₂O
Molecular Weight	310.43
SMILES	CC[C@@H]1[C@@]2([H])[C@]3([H])C4=C(CC[N@]2C[C@@](C1)([H])C3)C5=CC=C(OC)C=C5N4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.