TACA, or trans-4-Aminocrotonic acid, is a potent agonist of GABAA and GABAC receptors, exhibiting a dissociation constant (KD) of 0.6 μM. Additionally, TACA acts as a GABA uptake inhibitor and serves as a substrate for GABA-transaminase (GABA-T). Its unique properties allow for the production of late biphasic responses in MPG neurons, making it valuable for research into GABAergic signaling and pharmacological interventions targeting these receptors.
TACA, or trans-4-Aminocrotonic acid, is a potent agonist of GABAA and GABAC receptors, exhibiting a dissociation constant (KD) of 0.6 μM. Additionally, TACA acts as a GABA uptake inhibitor and serves as a substrate for GABA-transaminase (GABA-T). Its unique properties allow for the production of late biphasic responses in MPG neurons, making it valuable for research into GABAergic signaling and pharmacological interventions targeting these receptors.
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