Fig. 1 · Structure
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Tacrolimus 8-epimer
Immunosuppressive Agent
Tacrolimus 8-epimer, also known as Tacrolimus EP impurity D, is an immunosuppressive agent that acts primarily by inhibiting T cell proliferation. This compound exerts its biological activity through the suppression of various lymphokines, with a notable impact on interleukin-2 (IL-2) production. It is commonly utilized in research on transplant rejection, autoimmune diseases, and T cell biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 129212-35-7 |
| Applications | Immunosuppressive Agent |
| Formula | C44H69NO12 |
| Molecular Weight | 804.02 |
| Synonyms | Tacrolimus EP impurity D; 8-epi-Tacrolimus |
| SMILES | CO[C@@H]1[C@]2([H])O[C@]([C@@H](C1)C)(C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](CC([C@H](/C=C(C[C@@H](C[C@@H]2OC)C)\C)CC=C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.