Fig. 1 · Structure
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Tafetinib
Multi-targetsReceptorTyrosineKinasesInhibitor
Tafetinib is an oral multi-target receptor tyrosine kinases inhibitor, primarily acting on Kit, VEGFR-2, PDGFR-β, RET, and FLT3 with IC50 values ranging from 5.0 to 68.1 nmol/L. This compound effectively inhibits the phosphorylation of PDGFR-β and VEGFR-2, demonstrating significant biological activity in suppressing endothelial cell proliferation and chemotaxis, as well as corneal angiogenesis. Tafetinib serves as a valuable tool in cancer research and studies related to vascular biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1032265-57-8 |
| Applications | Multi-targetsReceptorTyrosineKinasesInhibitor |
| Formula | C24H29FN4O2 |
| Molecular Weight | 424.51 |
| Synonyms | SIM010603 |
| SMILES | CCN(CC)CCNC(C1=C(C)NC2=C1CCC/C2=C3C(NC4=CC=C(F)C=C/34)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.