Fig. 1 · Structure
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Taletrectinib free base
ROS1/NTRK Inhibitor
Taletrectinib free base is a selective inhibitor of ROS1 and NTRK signaling pathways, exhibiting potent oral bioactivity. It effectively inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50 values of 0.207 nM, 0.622 nM, 2.28 nM, and 0.98 nM, respectively. Additionally, Taletrectinib demonstrates efficacy against ROS1 G2032R and other Crizotinib-resistant ROS1 mutants, making it a valuable tool for cancer research and drug development targeting these pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1505514-27-1 |
| Applications | ROS1/NTRK Inhibitor |
| Formula | C23H24FN5O |
| Molecular Weight | 405.47 |
| Synonyms | DS-6051b free base; AB-106 free base; IBI-344 free base |
| SMILES | C[C@@H](NC1=NN2C(C=C1)=NC=C2C3=CC=C(OC[C@H](N)C)C=C3)C4=CC=CC(F)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.