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Talotrexin ammonium

Nonpolyglutamatable Antifolate

Talotrexin ammonium is a nonpolyglutamatable antifolate that primarily targets dihydrofolate reductase (DHFR). It exhibits potent antitumor activity across various cancer models by effectively inhibiting tumor growth. This compound is particularly useful in research applications exploring the mechanisms of antifolate resistance and the development of novel cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	678991-55-4
Applications	Nonpolyglutamatable Antifolate
Formula	C₂₇H₂₇N₉O₆.xH₃N
Synonyms	PT523 ammonium
SMILES	NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2.N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.