Fig. 1 · Structure
Documents & Downloads
Talotrexin monoammonium
Antifolate
Talotrexin monoammonium is a monoammonium salt of Talotrexin, functioning as a classic antifolate with a specific mechanism of action. It selectively inhibits the reduced folate carrier (RFC) transport, leading to the inhibition of dihydrofolate reductase (DHFR). This compound demonstrates significant antitumor activity, making it a valuable tool for research in cancer biology and therapeutic applications targeting folate metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 648420-92-2 |
| Applications | Antifolate |
| Formula | C27H30N10O6 |
| Molecular Weight | 590.59 |
| Synonyms | PT523 monoammonium |
| SMILES | NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2.N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.