Fig. 1 · Structure
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Talotrexin
Antifolate
Talotrexin is an antifolate compound that acts primarily as a selective inhibitor of the reduced folate carrier (RFC). By specifically targeting and inhibiting dihydrofolate reductase (DHFR), Talotrexin demonstrates significant antitumor activity, effectively constraining tumor growth. Its unique mechanism makes it valuable for research in cancer biology and the development of novel therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 113857-87-7 |
| Applications | Antifolate |
| Formula | C27H27N9O6 |
| Molecular Weight | 573.56 |
| Synonyms | PT523 |
| SMILES | NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.