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Tamoxifen

Name: Tamoxifen
Brand: Adooq Bioscience
SKU: A16738
Availability: InStock

Cat. No. A16738 CAS 10540-29-1

selective estrogen receptor modulator (SERM)

Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.

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Biological Activity

Target & Activity

Target	Activity	Value
Estrogen receptor
HSP90

Cellular Effect

Cell Line	Activity	Value	Description	Reference
518A2	IC50	7.62 μM	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 22749392]
A2058	EC50	12.5 μM	Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay	[PMID: 31099568]
A253 cell line	IC50	8.92 μM	Cytotoxicity against human A253 cells after 96 hrs by SRB assay	[PMID: 22749392]
A2780	GI50	30.3 μM	Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay	[PMID: 27128175]
A2780	IC50	7.77 μM	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 22749392]
A-431	IC50	> 100 μM	Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC50	1.86 μg/mL	Cytotoxicity against human A549 cells by alamar blue assay	[PMID: 11720540]
A549	IC50	10.08 μM	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
A549	IC50	10.87 μM	Antiproliferative activity against human A549 cells by MTT assay	[PMID: 31546197]
A549	IC50	12 μM	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 23287057]
A549	IC50	17.3 μM	Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC50	17.3 μM	Anticancer activity against human A549 cells measured after 48 hrs by SRB assay	[PMID: 27671497]
A549	GI50	24.4 μM	Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay	[PMID: 26163220]
A549	IC50	8.4 μM	Cytotoxicity against human A549 cells assessed as cell viability by MTT assay	[PMID: 26079090]
A549	IC50	9.66 μM	Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 22749392]
Astrocyte	IC50	> 10 μM	Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method	[PMID: 26355532]
B16-F10	IC50	64.87 μM	Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay	[PMID: 25222876]
CHO	IC50	> 100 μM	Antiproliferative activity against CHO cells after 2 days by MTT assay	[PMID: 25222876]
DLD-1	IC50	11.06 μM	Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay	[PMID: 27671497]
DLD-1	IC50	16.3 μM	Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	10540-29-1
Applications	selective estrogen receptor modulator (SERM)
Formula	C₂₆H₂₉NO
Molecular Weight	371.51
Synonyms	ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
SMILES	CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	68 mg/mL (183.03 mM)
Water	Insoluble
Ethanol	68 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 1 mg/mL
Vehicle: 2% DMSO+30% PEG 300+2% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.