Fig. 1 · Structure
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Tan-931
Aromatase Inhibitor
Tan-931 is a non-competitive and selective inhibitor of aromatase, exhibiting an IC50 of 17.2 μM for human aromatase and 162 μM for rat aromatase. This compound effectively reduces plasma estradiol-17β levels and diminishes the weight of ovaries and uterus in PMSG-treated female rats. Tan-931 serves as a valuable tool in the study of estrogen-dependent metastatic breast cancer, facilitating research into therapeutic strategies targeting aromatase activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 127448-92-4 |
| Applications | Aromatase Inhibitor |
| Formula | C15H10O7 |
| Molecular Weight | 302.24 |
| SMILES | O=CC1=CC(C(O)=O)=CC(O)=C1C(C2=C(O)C=CC=C2O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.