Targefrin is a potent EphA2-targeting agent that functions as an antagonist. It exhibits high affinity for the EphA2 ligand-binding domain, with a dissociation constant of 21 nM and an IC50 value of 10.8 nM. Targefrin induces internalization and degradation of the EphA2 receptor in various pancreatic cancer cell lines, making it a valuable tool for research on cancer biology and therapeutic targeting of EphA2-related pathways.
Targefrin is a potent EphA2-targeting agent that functions as an antagonist. It exhibits high affinity for the EphA2 ligand-binding domain, with a dissociation constant of 21 nM and an IC50 value of 10.8 nM. Targefrin induces internalization and degradation of the EphA2 receptor in various pancreatic cancer cell lines, making it a valuable tool for research on cancer biology and therapeutic targeting of EphA2-related pathways.
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