Fig. 1 · Structure
Documents & Downloads
TAS-4
iGluR
TAS-4 is a highly selective positive allosteric modulator of mGluR4, demonstrating significant activity in models of Parkinson's disease. It effectively reverses haloperidol-induced spasticity when administered alone and enhances contralateral rotation behavior in a dose-dependent manner when combined with l-DOPA. Notably, TAS-4 in conjunction with low-dose l-DOPA exhibits anti-Parkinson's effects comparable to those of higher doses of l-DOPA without increasing abnormal motor side effects, making it a valuable tool for Parkinson's disease research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 794544-99-3 |
| Applications | iGluR |
| Formula | C12H8Cl2N2O |
| Molecular Weight | 267.11 |
| SMILES | O=C(NC1=CC=C(C=C1Cl)Cl)C2=NC=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.