Fig. 1 · Structure
Documents & Downloads
TAS2940 fumarate
ERBB Inhibitor
TAS2940 fumarate is an irreversible and selective pan-ERBB inhibitor that effectively penetrates the blood-brain barrier. It demonstrates potent inhibitory activity against wild-type HER2, HER2 V777L, and A775_G776insYVMA, with IC50 values of 5.6 nM, 2.1 nM, and 1.0 nM, respectively. This compound is suitable for research applications focused on tumors characterized by HER2 and EGFR mutations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2758034-98-7 |
| Applications | ERBB Inhibitor |
| Formula | C32H34N6O6 |
| Molecular Weight | 598.65 |
| SMILES | OC(/C=C/C(O)=O)=O.NC1=NC=NC2=C1C(C(N[C@@H](C3=CC=CC=C3)C)=O)=C(C#CC4CC4)N2[C@@H]5C[C@H](C)N(C(C=C)=O)C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.