Fig. 1 · Structure
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TASP0433864
mGlu2 PAM
TASP0433864 is a selective positive allosteric modulator (PAM) of the metabotropic glutamate 2 (mGlu2) receptor, exhibiting EC50 values of 199 nM and 206 nM for human and rat mGlu2 receptors, respectively. This compound demonstrates significant antipsychotic activity, making it a valuable tool for research into neuropsychiatric disorders. Its ability to modulate mGlu2 receptor activity highlights its potential in studying glutamatergic signaling and developing new therapeutics for related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1431980-60-7 |
| Applications | mGlu2 PAM |
| Formula | C18H23N3O3 |
| Molecular Weight | 329.39 |
| SMILES | O=C(C1=C(C)N2C(O[C@H](COC3=CC=C(C(C)(C)C)C=C3)C2)=N1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.