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TASP0434299

V1B Receptor ligand

TASP0434299 is a radiolabeled ligand targeting the vasopressin V1b receptor. It demonstrates high binding affinity for human and murine V1B receptors, with IC50 values of 0.526 nM and 0.641 nM, respectively, and exhibits potent antagonistic activity at the human V1B receptor with an IC50 of 0.639 nM. TASP0434299 acts as a substrate for human and rhesus monkey P-glycoprotein, leading to low brain uptake. Additionally, it binds specifically and saturably to V1B receptors in rat and monkey pituitary tissues, making it suitable for in vivo and in vitro studies. When radiolabeled, it serves as an effective V1B receptor radiotracer for visualization in positron emission tomography.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1520893-08-6
Applications	V1B Receptor ligand
Formula	C₂₇H₃₅N₅O₅
Molecular Weight	509.61
SMILES	O=C1C2=CC(OCCCN3CCOCC3)=CN=C2N=C(C=4C=CC=C(OC)C4)N1CC(=O)NC(C)(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.