Fig. 1 · Structure
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TBPH
Brominated Flame Retardant
TBPH (Tetrabromophthalic Anhydride) is a brominated flame retardant that primarily targets lipid metabolism pathways. It enhances hepatic steatosis, inflammation, and fibrosis in models of nonalcoholic steatohepatitis (NASH) by inducing dysregulation of phospholipid metabolism, specifically decreasing cardiolipin and phosphatidylserine levels. Further, TBPH disrupts endoplasmic reticulum-mitochondria (ER-Mito) interactions, contributing to mitochondrial dysfunction and triggering lung injury through a mitochondria-derived inflammatory response. This compound is valuable for investigating MFN2-mediated ER-mitochondria contacts and their impact on lipid homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 26040-51-7 |
| Applications | Brominated Flame Retardant |
| Formula | C24H34Br4O4 |
| Molecular Weight | 706.14 |
| SMILES | O=C(OCC(CC)CCCC)C1=C(Br)C(Br)=C(Br)C(Br)=C1C(OCC(CC)CCCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.