Fig. 1 · Structure
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TC-2559 difumarate
α4β2 Partial Agonist
TC-2559 difumarate is a centrally active partial agonist targeting the α4β2 subtype of nicotinic acetylcholine receptors (nAChRs), with an EC50 of 0.18 μM. This compound demonstrates selectivity for α4β2 receptors over α2β4, α4β4, and α3β4 receptors, exhibiting EC50 values between 10-30 µM. TC-2559 difumarate is primarily used in research focused on antinociceptive effects and the modulation of CNS activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 2454492-41-0 |
| Applications | α4β2 Partial Agonist |
| Formula | C20H26N2O9 |
| Molecular Weight | 438.43 |
| SMILES | CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(/C=C/C(O)=O)O.O=C(/C=C/C(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.