TC-E 5001

Catalog No.: A11454

TNKS inhibitor

TC-E 5001

TC-E 5001 Chemical Structure

CAS NO. 865565-29-3

TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$500.00
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Biological Activity

TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.11 mL 244.22 mL
0.5 mM 4.88 mL 24.42 mL 48.84 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11454
Actions Inhibitor
CAS No. 865565-29-3
Formula C20H19N5O3S
M. Wt 409.46
Solubility DMSO
Purity >98%
Synonyms TC-E5001, TC-E-5001
SMILES CC(N1C(C=C2)=CC=C2OC)=NN=C1SCC3=NC(C(C=C4)=CC=C4OC)=NO3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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