TC-N 22A is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4), exhibiting an EC50 of 9 nM in human mGlu4-expressing BHK cells. This compound demonstrates minimal activity at other mGlu receptors (EC50 > 10 μM), including mGlu1, 2, 3, 5, and 7. TC-N 22A is suitable for in vivo research studies focused on central nervous system diseases, offering insights into mGlu4-mediated pathways.
TC-N 22A is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4), exhibiting an EC50 of 9 nM in human mGlu4-expressing BHK cells. This compound demonstrates minimal activity at other mGlu receptors (EC50 > 10 μM), including mGlu1, 2, 3, 5, and 7. TC-N 22A is suitable for in vivo research studies focused on central nervous system diseases, offering insights into mGlu4-mediated pathways.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
