Fig. 1 · Structure
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TC299423
nAChRs Agonist
TC299423 is a selective and potent agonist of the α6β2 and α4β2 nicotinic acetylcholine receptors (nAChRs) with significant anxiolytic and antinociceptive properties. This orally active compound effectively penetrates the blood-brain barrier and primarily targets the α6β2 nAChRs, which are associated with the anxiolytic effects of nicotine. Research indicates that TC299423 induces reward-related behaviors in α6L90’S hypersensitive mice and stimulates dopamine release without inhibiting nicotine self-administration in rats. Its pharmacological profile suggests potential applications in the study of addiction and Parkinson's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1975146-56-5 |
| Applications | nAChRs Agonist |
| Formula | C11H15N3 |
| Molecular Weight | 189.26 |
| SMILES | C1(/C2=CN=CN=C2)=C\CCNCCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.