Fig. 1 · Structure
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TCJL37
TYK2 Inhibitor
TCJL37 is a potent and selective inhibitor of TYK2, exhibiting a Ki of 1.6 nM. This compound demonstrates significant potential for research applications related to inflammatory bowel diseases (IBD). Its oral bioavailability makes it a valuable tool for studying the role of TYK2 in immune responses and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1258294-34-6 |
| Applications | TYK2 Inhibitor |
| Formula | C17H11ClF2N4O2 |
| Molecular Weight | 376.74 |
| SMILES | O=C(NC1=CC(NC([C@@H]2[C@H](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.