TCL1(10-24) is a specific Akt inhibitor that targets the PH domain of Akt, disrupting its interaction with phosphoinositides. This inhibition prevents Akt's membrane translocation and subsequent activation, thereby hindering cellular proliferation and promoting apoptosis. TCL1(10-24) demonstrates significant antitumor activity in vivo, making it a valuable reagent for cancer research and studies focused on cell survival mechanisms.
TCL1(10-24) is a specific Akt inhibitor that targets the PH domain of Akt, disrupting its interaction with phosphoinositides. This inhibition prevents Akt's membrane translocation and subsequent activation, thereby hindering cellular proliferation and promoting apoptosis. TCL1(10-24) demonstrates significant antitumor activity in vivo, making it a valuable reagent for cancer research and studies focused on cell survival mechanisms.
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