TCN 213 is a selective, surmountable antagonist of the GluN1/GluN2A subunits of the N-methyl-D-aspartate receptor (NMDAR), exhibiting IC50 values of 0.55, 3.5, and 40 μM in the presence of 75, 750, and 7500 nM glycine, respectively. This compound serves a critical role in studying the pharmacological modulation of NMDAR expression in developing cortical neurons, making it a valuable tool for research in neurodevelopment and synaptic plasticity.
TCN 213 is a selective, surmountable antagonist of the GluN1/GluN2A subunits of the N-methyl-D-aspartate receptor (NMDAR), exhibiting IC50 values of 0.55, 3.5, and 40 μM in the presence of 75, 750, and 7500 nM glycine, respectively. This compound serves a critical role in studying the pharmacological modulation of NMDAR expression in developing cortical neurons, making it a valuable tool for research in neurodevelopment and synaptic plasticity.
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