Fig. 1 · Structure
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TCS 46b
NR1A/2B Antagonist
TCS 46b is a selective NMDA NR1A/2B receptor antagonist with an IC50 value of 5.3 nM, demonstrating potent activity in modulating excitatory neurotransmission. Its unique structure allows it to serve as a click chemistry reagent, featuring an alkyne group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. This compound is valuable for researchers investigating neuropharmacology and developing novel therapeutic strategies targeting NMDA receptor modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 302799-86-6 |
| Applications | NR1A/2B Antagonist |
| Formula | C22H23N3O |
| Molecular Weight | 345.44 |
| SMILES | O=C1NC2=CC=C(C=C2N1)C#CCN3CCC(CC3)CC4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.