TD-522 is a potent and selective molecular glue targeting GSPT1 for degradation, exhibiting a DC50 of 0.269 nM. This compound demonstrates significant anti-proliferative activity and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cell lines. Additionally, TD-522 effectively suppresses tumor growth in a TMD-8 xenograft model. It is applicable for research focused on AML and DLBCL.
TD-522 is a potent and selective molecular glue targeting GSPT1 for degradation, exhibiting a DC50 of 0.269 nM. This compound demonstrates significant anti-proliferative activity and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cell lines. Additionally, TD-522 effectively suppresses tumor growth in a TMD-8 xenograft model. It is applicable for research focused on AML and DLBCL.
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