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TDG-IN-1

TDG Inhibitor

TDG-IN-1 is a selective small-molecule inhibitor of thymine DNA glycosylase (TDG) that demonstrates strong inhibitory activity with a Ka of 1.46 nM. This compound disrupts TDG's DNA-binding capabilities, leading to reduced expression of DHX9, increased accumulation of double-stranded RNA, and subsequent activation of the RIG-I/MDA5-MAVS pathway. As an innate immune activator and tumor suppressor, TDG-IN-1 is effective in inhibiting the growth of p53-deficient tumor cells and xenograft tumors, providing a synthetic lethal effect in conjunction with p53 deficiency. This reagent is valuable for research focused on p53-deficient cancers.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3092641-80-7
Applications	TDG Inhibitor
Formula	C₁₃H₁₄O₄
Molecular Weight	234.25
SMILES	O=C1C2CC2C(C3=CC(C)=C(O)C=C3OC)O1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.