Fig. 1 · Structure
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tDHU, acid
E3 Ubiquitin Ligase Ligand-Linker Conjugate
tDHU, acid is an E3 Ubiquitin Ligase ligand-linker conjugate featuring a dihydropyrimidine core and a benzoic acid linker. This compound facilitates the design and development of Proteolysis Targeting Chimeras (PROTACs), which are innovative therapeutic agents aimed at targeted protein degradation. Its specific interaction with E3 ligases allows for the modulation of cellular protein levels, making tDHU, acid valuable in research focused on protein regulation and therapeutic discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2377643-37-1 |
| Applications | E3 Ubiquitin Ligase Ligand-Linker Conjugate |
| Formula | C12H12N2O4 |
| Molecular Weight | 248.23 |
| SMILES | O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.