Fig. 1 · Structure
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TDI-11861
sAC Inhibitor
TDI-11861 is a potent inhibitor of soluble adenylyl cyclase (sAC), featuring an IC50 of 3.3 nM and a KD of 1.4 nM. This compound exhibits high affinity, slow dissociation, and favorable pharmacokinetic properties, making it suitable for in-depth studies. TDI-11861 is particularly valuable for research focused on male contraception and the pharmacological roles of sAC in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2857049-72-8 |
| Applications | sAC Inhibitor |
| Formula | C22H25ClF2N6O3 |
| Molecular Weight | 494.92 |
| SMILES | NC1=NC(C2=NN(C=C2CC3=C(C=CC=C3)OCCN4CCOC[C@H]4CO)C(F)F)=CC(Cl)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.