Fig. 1 · Structure

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TDI-8304

Pf20S Inhibitor

TDI-8304 is a macrocyclic peptide that functions as a selective noncovalent inhibitor of the Plasmodium falciparum 20S proteasome. This compound exhibits significant selectivity for the Pf20S over human proteasomes, making it a valuable tool for studying malaria biology and proteasome-mediated processes. Its potent inhibitory action enables researchers to investigate the role of proteasomes in Plasmodium falciparum proliferation and develop potential therapeutic strategies against malaria.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2307262-96-8
Applications Pf20S Inhibitor
Formula C32H47N5O6
Molecular Weight 597.75
SMILES
O=C1[C@@H](N2C(CCC2)=O)CC3=CC=CC(OCCCC[C@H](NC([C@@H](N1)CCN4CCOCC4)=O)C(NC5CCCC5)=O)=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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