Fig. 1 · Structure
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TDO-IN-1
TDO Inhibitor
TDO-IN-1 is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO) that exhibits remarkable specificity over indoleamine-2,3-dioxygenase (IDO), displaying an IC50 value of 0.62 μM for IDO. This compound has been shown to reverse local immune tolerance within tumor microenvironments, effectively inhibiting tumor growth in vivo. TDO-IN-1 is a valuable tool for research focused on cancer immunotherapy and the modulation of immune responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2490672-92-7 |
| Applications | TDO Inhibitor |
| Formula | C16H13F3N4O2 |
| Molecular Weight | 350.30 |
| SMILES | FC(C1=CC2=C(C(NCC3=CC=C(C)C=C3[N+]([O-])=O)=C1)C=NN2)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.