Fig. 1 · Structure
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TDP1 Inhibitor-2
TDP1 Inhibitor
TDP1 Inhibitor-2 is a selective inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP1), demonstrating potent inhibition with an IC50 value of 99 nM. Additionally, it exhibits inhibitory effects on SCAN1, presenting an IC50 of 3.5 μM. This compound is valuable for studying DNA repair mechanisms and exploring therapy potential in related neurodegenerative conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 859142-95-3 |
| Applications | TDP1 Inhibitor |
| Formula | C25H14Cl2O5 |
| Molecular Weight | 465.28 |
| SMILES | ClC1=CC=CC(Cl)=C1COC2=CC=C(C(C3=CC(C=CC=C4)=C4OC3=O)=CC(O5)=O)C5=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.