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TDPAM01

GluA2 Receptor Positive Allosteric Modulator

TDPAM01 is a positive allosteric modulator targeting the AMPA receptor GluA2. It specifically binds to the ligand-binding domain of the GluA2 flop subtype with an IC50 of 13.4 nM, effectively stabilizing its activated conformation. This modulation delays receptor deactivation and desensitization, facilitating sustained excitatory synaptic transmission in the central nervous system, making it valuable for research on synaptic plasticity and neuronal signaling.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	2231103-08-3
Applications	GluA2 Receptor Positive Allosteric Modulator
Formula	C₁₈H₂₂N₄O₄S₂
Molecular Weight	422.52
SMILES	O=S1(=O)NCN(C2=CC(=CC=C21)CCC3=CC=C4C(=C3)N(C)CNS4(=O)=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.