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TDPAM02

GluA2 Receptor Positive Allosteric Modulator

TDPAM02 is a positive allosteric modulator targeting the AMPA receptor GluA2. It binds specifically to the ligand-binding domain (LBD) of the GluA2 flop subtype, exhibiting an IC50 value of 1.4 nM. By stabilizing the activated conformation of GluA2 receptors, TDPAM02 effectively delays receptor deactivation and desensitization. This compound is valuable for research focused on enhancing excitatory synaptic transmission in the central nervous system.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	2231101-34-9
Applications	GluA2 Receptor Positive Allosteric Modulator
Formula	C₂₂H₂₆N₄O₄S₂
Molecular Weight	474.59
SMILES	O=S1(=O)NCN(C2=CC(=CC=C21)CCC3=CC=C4C(=C3)N(CNS4(=O)=O)C5CC5)C6CC6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.