Fig. 1 · Structure
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TDRL-551
RPA Inhibitor
TDRL-551 is a potent inhibitor of replication protein A (RPA), exhibiting an IC50 of 18 µM. This compound disrupts the interaction between RPA and DNA, thereby enhancing the efficacy of platinum-based chemotherapy agents in cancer treatment. TDRL-551 is particularly relevant for research in cancers like non-small cell lung cancer (NSCLC), providing insights into strategies for overcoming chemoresistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1644626-43-6 |
| Applications | RPA Inhibitor |
| Formula | C25H23ClIN3O4 |
| Molecular Weight | 591.83 |
| SMILES | O=C(CCCC(N1N=C(CC1C2=CC3=CC=C(C=C3N=C2Cl)OCC)C4=CC=C(C=C4)I)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.