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Tegaserod-d11

Catalog No.: A31717
Stable Isotope
Tegaserod-d11 is a deuterated analog of Tegaserod, a selective agonist of the serotonin receptor 4 (HTR4) and a potent antagonist of the 5-HT2B receptor. With pKis of 7.5, 8.4, and 7.0 for the human recombinant 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, Tegaserod exhibits significant biological activity by inducing tumor cell apoptosis, inhibiting PI3K/Akt/mTOR signaling, and reducing S6 phosphorylation. This reagent is valuable for research applications focusing on anti-tumor effects and the pathophysiology of irritable bowel syndrome (IBS).
Tegaserod-d11 1134188-56-9 Stable Isotope
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTegaserod-d11 is a deuterated analog of Tegaserod, a selective agonist of the serotonin receptor 4 (HTR4) and a potent antagonist of the 5-HT2B receptor. With pKis of 7.5, 8.4, and 7.0 for the human recombinant 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, Tegaserod exhibits significant biological activity by inducing tumor cell apoptosis, inhibiting PI3K/Akt/mTOR signaling, and reducing S6 phosphorylation. This reagent is valuable for research applications focusing on anti-tumor effects and the pathophysiology of irritable bowel syndrome (IBS).
Product Information
Catalog NumA31717
FormulaC16H12D11N5O
Molecular Weight312.45
CAS Number1134188-56-9
SMILESN=C(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N/N=C/C1=CNC2=CC=C(OC)C=C21
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Isotope-Labeled Compounds